| Georgia Senate | D★ Jon OssoffR Mike Collins | $84.7M | $1.78M |
| Texas Senate | D James TalaricoR Ken Paxton | $77.8M | $31.2M |
| Ohio Senate (special) Special election | D Sherrod BrownR★ Jon HustedI Gregory Lee Levy | $53.0M | $6.84M |
| North Carolina Senate | D Roy CooperR Michael WhatleyG Michael Louis Dublin Jr. | $46.3M | $7.80M |
| Alaska Senate | D Mary PeltolaR★ Dan S. Sullivan | $27.7M | $4.21M |
| Michigan Senate | D Abdul El-SayedR Mike Rogers | $25.4M | $35.3M |
| New Jersey Senate | D★ Cory BookerR Justin Murphy | $18.9M | $0 |
| Virginia Senate | D★ Mark WarnerR Bert Mizusawa | $18.3M | $150K |
| Nebraska Senate | R★ Pete RickettsI Dan OsbornOth Cindy BurbankOth Mike Marvin | $17.1M | $2.27M |
| New Hampshire Senate | D Chris PappasR John Sununu | $17.0M | $2.90M |
| Iowa Senate | R Ashley HinsonD Josh TurekL Thomas Raymond Laehn | $16.5M | $9.03M |
| Maine Senate | R★ Susan CollinsD Troy Jackson | $16.2M | $4.60M |
| Florida Senate (special) Special election | R★ Ashley MoodyD Angie Nixon | $12.2M | $472K |
| Minnesota Senate | D Peggy FlanaganR Michele Tafoya | $11.8M | $7.44M |
| Kentucky Senate | R Andy BarrD Charles Booker | $11.1M | $14.2M |
| South Carolina Senate | D Annie AndrewsR★ Darline Graham | $10.8M | $146K |
| Oklahoma Senate | R Kevin HernD N'Kiyla Jasmine Thomas | $10.0M | $2.38M |
| Colorado Senate | D★ John HickenlooperOth Bob ChewR Mark BaisleyOth Sean M. Pond | $9.56M | $510K |
| Arkansas Senate | R★ Tom CottonD Hallie ShoffnerL Jeffrey Francis Wadlin | $8.53M | $3.21M |
| Illinois Senate | D Juliana StrattonR Don TracyI Whitfield Harrington Jr. | $8.47M | $19.9M |
| Louisiana Senate | R Julia LetlowD Jamie Davis | $8.19M | $14.4M |
| Kansas Senate | D Adam HamiltonR★ Roger Marshall | $8.18M | $228K |
| Tennessee Senate | R★ Bill HagertyD Marquita Bradshaw | $7.17M | $551K |
| Massachusetts Senate | D★ Ed MarkeyR John DeatonOth Joseph TacheI Shiva Ayyadurai | $6.52M | $1.48M |
| Mississippi Senate | R★ Cindy Hyde-SmithD Scott ColomI Ty Pinkins | $6.31M | $570K |
| New Mexico Senate | D Ben Ray LujánR Larry Marker | $5.66M | $0 |
| Montana Senate | I Seth BodnarR Kurt AlmeL Kyle AustinD Alani Bankhead | $5.54M | $8.59M |
| West Virginia Senate | R★ Shelley Moore CapitoD Rachel Fetty Anderson | $4.67M | $338K |
| Oregon Senate | D★ Jeff MerkleyR David Brock Smith | $4.66M | $0 |
| Delaware Senate | D★ Christopher A. CoonsR John ShulliR Michael S. Katz | $4.12M | $0 |
| Idaho Senate | Oth★ Jim RischI Todd Achilles | $4.05M | $0 |
| South Dakota Senate | R★ Mike RoundsI Brian Bengs | $3.96M | $486K |
| Alabama Senate | R Barry MooreD Everett Wess | $3.87M | $9.06M |
| Rhode Island Senate | D★ Jack ReedR Raymond McKay | $3.29M | $0 |
| Wyoming Senate | R Harriet HagemanD James W. Byrd | $2.46M | $446K |