| Texas Senate | D James TalaricoR Ken Paxton | $168.7M | $34.0M |
| Georgia Senate | D★ Jon OssoffR Mike Collins | $126.6M | $1.99M |
| Ohio Senate (special) Special election | D Sherrod BrownR★ Jon HustedI Gregory Lee Levy | $88.4M | $10.7M |
| Michigan Senate | D Abdul El-SayedR Mike Rogers | $76.8M | $49.1M |
| North Carolina Senate | D Roy CooperR Michael WhatleyG Michael Louis Dublin Jr. | $63.3M | $16.8M |
| Maine Senate | D Troy JacksonR★ Susan Collins | $49.3M | $5.78M |
| Alaska Senate | D Mary PeltolaR★ Dan S. Sullivan | $48.4M | $7.56M |
| Iowa Senate | D Josh TurekR Ashley HinsonL Thomas Raymond Laehn | $38.5M | $25.0M |
| New Hampshire Senate | D Chris PappasR John Sununu | $29.4M | $4.89M |
| South Carolina Senate | D Annie AndrewsR★ Darline Graham | $26.1M | $2.85M |
| Florida Senate (special) Special election | R★ Ashley MoodyD Angie Nixon | $25.8M | $662K |
| Nebraska Senate | R★ Pete RickettsI Dan OsbornOth Cindy BurbankOth Mike Marvin | $25.7M | $1.46M |
| Kansas Senate | D Adam HamiltonR★ Roger Marshall | $24.5M | $282K |
| Minnesota Senate | R Michele TafoyaD Peggy Flanagan | $24.1M | $8.16M |
| Virginia Senate | D★ Mark WarnerR Bert Mizusawa | $21.4M | $150K |
| New Jersey Senate | D★ Cory BookerR Justin Murphy | $21.3M | $135 |
| Kentucky Senate | R Andy BarrD Charles Booker | $14.5M | $15.3M |
| Colorado Senate | D★ John HickenlooperOth Bob ChewR Mark BaisleyOth Sean M. Pond | $13.3M | $510K |
| Illinois Senate | D Juliana StrattonR Don TracyI Whitfield Harrington Jr. | $12.3M | $19.6M |
| Louisiana Senate | R Julia LetlowD Jamie Davis | $12.1M | $22.4M |
| Arkansas Senate | R★ Tom CottonD Hallie ShoffnerL Jeffrey Francis Wadlin | $11.3M | $2.54M |
| Oklahoma Senate | R Kevin HernD N'Kiyla Jasmine Thomas | $11.0M | $2.45M |
| Mississippi Senate | R★ Cindy Hyde-SmithD Scott ColomI Ty Pinkins | $9.15M | $2.42M |
| Tennessee Senate | R★ Bill HagertyD Marquita Bradshaw | $8.46M | $800K |
| Montana Senate | I Seth BodnarR Kurt AlmeL Kyle AustinD Alani Bankhead | $8.38M | $6.97M |
| Massachusetts Senate | D★ Ed MarkeyR John DeatonOth Joseph TacheI Shiva Ayyadurai | $8.19M | $18K |
| New Mexico Senate | D Ben Ray LujánR Larry Marker | $6.56M | $319 |
| Idaho Senate | Oth★ Jim RischI Todd Achilles | $5.86M | $0 |
| Oregon Senate | D★ Jeff MerkleyR David Brock Smith | $5.69M | $25K |
| South Dakota Senate | R★ Mike RoundsI Brian Bengs | $5.67M | $566K |
| West Virginia Senate | R★ Shelley Moore CapitoD Rachel Fetty Anderson | $5.61M | $338K |
| Delaware Senate | D★ Christopher A. CoonsR Michael S. KatzR John Shulli | $5.27M | $12K |
| Alabama Senate | R Barry MooreD Everett Wess | $4.76M | $16.5M |
| Rhode Island Senate | D★ Jack ReedR Raymond McKay | $3.93M | $10 |
| Wyoming Senate | R Harriet HagemanD James W. Byrd | $2.86M | $1.04M |